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Benzylphenylephrone hydrochloride | CAS 71786-67-9

The hydrochloride of an N-benzyl amino ketone documented as phenylephrine related compound E, where salt identity, ketone integrity and the distinction between synthesis grade and qualified reference material govern purchasing decisions.

CAS71786-67-9
Molecular formulaC16H18ClNO2

Product overview

Benzylphenylephrone hydrochloride retains a meta-hydroxyphenyl ketone and an N-benzyl-N-methylamino group. The carbonyl is still present at the site converted to an alcohol in phenylephrine chemistry, and the nitrogen retains its benzyl substituent. CAS 71786-67-9 specifies the hydrochloride form. Also identified as phenylephrine related compound E, it has a role in impurity analysis as well as intermediate chemistry. Define whether the intended use is synthesis, peak identification or quantitative calibration, since these uses require different analytical qualification. For quantitative work, agree the assigned content and whether it is expressed as received, dried or as free-base equivalent, with the appropriate water, solvent and salt corrections.

Chemical identity

Chemical name
Benzylphenylephrone hydrochloride
CAS number
71786-67-9
Molecular formula
C16H18ClNO2

Application context

Phenylephrine impurity analysis uses benzylphenylephrone hydrochloride as related compound E. The intended role may be peak identification, an impurity challenge or quantitative calibration. For calibration, request an assigned content value and its supporting qualification and traceability. Confirm the hydrochloride basis and account for water and solvents as required by the method. The ketone and N-benzyl groups distinguish it from reduced or debenzylated members of the same chemical family.

Chemistry and synthetic role

The molecule contains a phenol meta to the amino-ketone side chain. Nitrogen is benzyl- and methyl-substituted and present as a hydrochloride salt. The ketone has no alcohol stereocentre; describing this material as racemic phenylephrine would misidentify the structure.

Quality review

Confirm the ketone structure

Ask for spectral evidence separating the carbonyl compound from reduced amino-alcohol analogues. The presence of a benzyl group should also be confirmed.

Establish salt and content basis

Specify the hydrochloride and determine whether any reported content is as received, dried or calculated as free base. Agree water and solvent corrections for quantitative use.

Qualify the intended standard role

For analytical calibration, request the assigned value and its supporting qualification. A routine purity COA does not by itself establish reference-standard traceability.

Preparing a specification

State phenylephrine related compound E hydrochloride, CAS 71786-67-9, and whether the request is for synthesis, peak identification or quantitative calibration. Define assigned-content requirements, salt basis and relevant impurity resolution.

Packaging and storage

Confirm packaging format, net weight and transport arrangements for the selected grade, order quantity and destination. Request the applicable SDS and label to establish storage and handling conditions.

Documentation

Request identity spectra and chromatographic data. For a reference-material application, ask for the assignment procedure and traceability evidence appropriate to the intended method; confirm COA, SDS and storage instructions for the actual grade.

Procurement questions

What is needed for quantitative reference use?

Request the assigned content, its qualification and traceability information, together with the salt, water and solvent basis applicable to the intended method.

Does this material need phenylephrine optical purity?

It is a ketone without the corresponding alcohol stereocentre; the identity should not be confused with phenylephrine.

Can chromatographic purity be used as potency?

Only if the qualification justifies that calculation; salt, water and solvents must be addressed.

Technical sources
  1. Phenylephrine Related Compound E, PHR1712Supelco / Sigma-Aldrich
  2. Phenylephrine Related Compound E, USP 1533046 SDSUS Pharmacopeia branded SDS via Fisher Scientific

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