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HONGKUN / PRODUCT DIRECTORY

2-Mercapto-5-methyl-1,3,4-thiadiazole | CAS 29490-19-5

A methylthiadiazole sulfur building block also identified as cefazolin impurity E, with procurement requirements that differ between synthesis material and analytical reference standards.

CAS29490-19-5
Molecular formulaC3H4N2S2
Molecular weight132.21 g/mol

Product overview

The ring in this compound contains two nitrogens and one sulfur, with a methyl group and a thiol/thione function at its carbon positions. Its cefazolin-related analytical identity makes chemical form and grade particularly relevant. A synthesis-grade batch and a reference standard may contain the same molecule but provide different assigned values, uncertainty information and traceability.

Chemical identity

Chemical name
2-Mercapto-5-methyl-1,3,4-thiadiazole
CAS number
29490-19-5
Molecular formula
C3H4N2S2
Molecular weight
132.21 g/mol

Application context

This compound is marketed in dedicated reference-material grades as cefazolin impurity E. It is therefore relevant to development or verification of chromatographic methods for cefazolin-related substances. In that setting, the assigned content and certificate scope matter alongside identity. For sulfur-heterocycle synthesis, attention shifts to reactive-content assay and related species, including potential oxidation products. Choose the purchasing specification around the intended analytical or synthetic role.

Chemistry and synthetic role

Thiol and thione descriptions refer to tautomeric representations of the sulfur-bearing heterocycle; they should not be confused with a methyl-substituted tetrazole.

Quality review

Reference or synthesis grade

For quantitative impurity work, request the assigned value and certificate scope rather than assuming area purity is a certified content.

Ring identity

Confirm the methyl-1,3,4-thiadiazole structure and its sulfur functionality.

Oxidative coupling

Review related sulfur species using an appropriate chromatographic method.

Preparing a specification

Identify the intended role as synthesis input or analytical standard. Specify assay basis, related substances and, for quantitative standards, assigned value and traceability requirements.

Packaging and storage

Confirm container compatibility, closure and net weight for the selected grade and destination. Follow the actual supplier SDS and batch label for storage and transport.

Documentation

Request the batch COA, SDS and analytical methods covering the agreed purchasing specification. Confirm which supporting chromatograms and application-specific records are available from the selected manufacturer.

Procurement questions

Why is it called cefazolin impurity E?

That designation is used for this molecule in dedicated cefazolin reference-material catalogues.

Can bulk material replace a quantitative reference standard?

Only after establishing its identity, assigned content and suitability for the analytical method.

Is it a methylmercaptotetrazole?

No; its ring is a thiadiazole containing two nitrogen atoms and one sulfur atom.

Technical sources
  1. PubChem CAS identity lookupNCBI / PubChem
  2. Cefazolin Impurity ESupelco
  3. 2-Mercapto-5-methyl-1,3,4-thiadiazoleTCI

Continue your research

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Related records support catalogue navigation; they are not recommendations for equivalent or interchangeable materials.